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​Selected Publications

2018

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury.
Matthias Kohlhauer
, Sam Dawkins, Ana S. H. Costa, Regent Lee, Timothy Young, Victoria R. Pell, Robin P. Choudhury, Adrian P. Banning, Rajesh K. Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb‐Parsy, Michael P. Murphy, Christian Frezza, Thomas Krieg, Keith M. Channon

JAHA. 2018 Apr https://doi.org/10.1161/JAHA.117.007546

2017
Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.
Chouchani ET, James AM, Methner C, Pell VR, Prime TA, Erickson BK, Forkink M, Lau GY, Bright TP, Menger KE, Fearnley IM, Krieg T, Murphy MP.
J Biol Chem. 2017 Sep 1;292(35):14486-14495. doi: 10.1074/jbc.M117.798744. Epub 2017 Jul 14. PMID: 28710281

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Pell VR, Chouchani ET, Frezza C, Murphy MP, Krieg T.
Cardiovasc Res. 2016 Jul 15;111(2):134-41. doi: 10.1093/cvr/cvw100. Epub 2016 May 18. Review.

 Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T.
Circ Res. 2016 Mar 4;118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569. Review.

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP.
Cell Metab. 2016 Feb 9;23(2):254-63. doi: 10.1016/j.cmet.2015.12.009. Epub 2016 Jan 14. Review.


2016

​
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
​Cardiovasc Res. doi:10.1093/cvr/cvw100
Pell, V. R., Chouchani, E. T., Frezza, C., Murphy, M. P., & Krieg, T.

Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Circ Res.118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569
Pell, V.R., Chouchani, E.T., Murphy, M.P., Brookes, P.S., Krieg, T. 

​A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Cell Metab. 23(2), 254–263. doi:10.1016/j.cmet.2015.12.009
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., Murphy, M. P.


2015
​

Logan A*, Pell VR*, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM,  Porteous CM, Partridge L, Krieg T, Smith RAJ and Murphy MP.
Assessing the mitochondrial membrane potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.
Cell Metab. 23, 379–385. doi:10.1016/j.cmet.2015.11.014

Evans E, Buonincontri G, Izquierdo D, Methner C, Hawkes RC, Ansorge RE, Krieg T, Carpenter TA, Sawiak SJ.
Combining MRI with PET for partial volume correction improves image-derived input functions in mice.
IEEE Trans Nucl Sci. 62(3 Pt 1):628-633. doi:10.1186/2197-7364-1-S1-A84​

2014

Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord EN, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa AS, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Nature. doi: 10.1038/nature13909.

Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T. 
Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.
Eur J Heart Fail. 16(7):712-7. doi: 10.1002/ejhf.100.

Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter, Stephen J. Sawiak.
Trajectory correction for free-breathing radial cine MRI.
Magn Reson Imaging. doi: 10.1016/j.mri.2014.04.006.

Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter and Stephen J. Sawiak
Functional assessment of the mouse heart by MRI with a 1-min acquisition.
NMR Biomed. doi: 10.1002/nbm.3116

Edward T. Chouchani, Chou-Hui Hu, Guido Buonincontri, Carmen Methner, Angela Logan, Chou-Hui Hu, Stephen J. Sawiak, Michael P. Murphy, and Thomas Krieg. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.
PLoS One, 10.1371/journal.pone.0094157

2013

Carmen Methner,  Guido Buonincontri,  Chou-Hui Hu,  Ana Vujic,  Axel Kretschmer,  Stephen Sawiak,  Adrian Carpenter,  Johannes-Peter Stasch,  Thomas Krieg.
Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging.
PLoS One, 10.1371/journal.pone.0083910

Guido Buonincontri, Carmen Methner, T. Adrian Carpenter, Robert C. Hawkes, Stephen J. Sawiak, Thomas Krieg.
MRI and PET in mouse models of myocardial infarction.
J Vis Exp. doi: 10.3791/50806.

Edward T. Chouchani, Carmen Methner, Sergiy M. Nadtochiy, Angela Logan, Victoria R. Pell, Shujing Ding, Andrew M. James, Helena M. Cochemé, Johannes Reinhold, Kathryn S. Lilley, Linda Partridge, Ian M. Fearnley, Alan J. Robinson, Richard C. Hartley, Robin A.J. Smith, Thomas Krieg, Paul S. Brookes, and Michael P. Murphy. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. 
Nature Medicine. 19, 753-759.
(Download)   (Nature Medicine: News and Views)   (BBC News coverage)

Angela Logan, Helena M. Cochemé, Pamela Boon Li Pun, Nadezda Apostolova, Robin A. J. Smith, Lesley Larsen, David S. Larsen, Andrew M. James, Ian M. Fearnley, Sebastian Rogatti, Tracy A. Prime, Peter Finichiu, Anna Dare, Edward T. Chouchani, Victoria R. Pell, Carmen Methner, Caroline Quin, Stephen J. McQuaker, Thomas Krieg, Richard C. Hartley, Michael P. Murphy. 
Using exomarkers to assess mitochondrial reactive species in vivo. 
Biochimica Biophysica Acta. 1840(2):923-30 doi: 10.1016/j.bbagen.2013.05.026.
(Download)

Carmen Methner, Robert Lukowski, Karina Grube, Florian Loga, Robin A. J. Smith, Michael P. Murphy, Franz Hofmann, Thomas Krieg.
Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G.
Basic Research in Cardiology. 108, 337.
(Download)

Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter, Stephen J. Sawiak.
A fast protocol for infarct quantification in mice.
Journal of Magnetic Resonance Imaging. 38(2):468-73. (DOI: 10.1002/jmri.24001)
(Download)

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