Selected Publications
2023
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Mottahedin A, Prag HA, Dannhorn A, Mair R, Schmidt C, Yang M, Sorby-Adams A, Lee JJ, Burger N, Kulaveerasingam D, Huang MM, Pluchino S, Peruzzotti-Jametti L, Goodwin R, Frezza C, Murphy MP, Krieg T.Redox Biol. 2023 Feb;59:102600. doi: 10.1016/j.redox.2023.102600. Epub 2023 Jan 2.PMID: 36630820
2022
Cyclophilin D knockout mice do not accumulate succinate during cardiac ischemia.
Prag HA, Kula-Alwar D, Bernardi P, Di Lisa F, Murphy MP, Krieg T.J Mol Cell Cardiol. 2022 Dec;173:73-74. doi: 10.1016/j.yjmcc.2022.09.006. Epub 2022 Oct 6.PMID: 36209553
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury.
Prag HA, Aksentijevic D, Dannhorn A, Giles AV, Mulvey JF, Sauchanka O, Du L, Bates G, Reinhold J, Kula-Alwar D, Xu Z, Pellerin L, Goodwin RJA, Murphy MP, Krieg T.Circ Res. 2022 Sep 2;131(6):528-541. doi: 10.1161/CIRCRESAHA.121.320717. Epub 2022 Aug 12.PMID: 35959683
ND3 Cys39 in complex I is exposed during mitochondrial respiration.
Burger N, James AM, Mulvey JF, Hoogewijs K, Ding S, Fearnley IM, Loureiro-López M, Norman AAI, Arndt S, Mottahedin A, Sauchanka O, Hartley RC, Krieg T, Murphy MP.Cell Chem Biol. 2022 Apr 21;29(4):636-649.e14. doi: 10.1016/j.chembiol.2021.10.010. Epub 2021 Nov 4.PMID: 34739852
Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury.
Miljkovic JL, Burger N, Gawel JM, Mulvey JF, Norman AAI, Nishimura T, Tsujihata Y, Logan A, Sauchanka O, Caldwell ST, Morris JL, Prime TA, Warrington S, Prudent J, Bates GR, Aksentijević D, Prag HA, James AM, Krieg T, Hartley RC, Murphy MP.Redox Biol. 2022 Aug 5;55:102429. doi: 10.1016/j.redox.2022.102429. Online ahead of print.PMID: 35961099
2021
Mitochondria as Therapeutic Targets in Transplantation.
Saeb-Parsy K, Martin JL, Summers DM, Watson CJE, Krieg T, Murphy MP.Trends Mol Med. 2021 Feb;27(2):185-198. doi: 10.1016/j.molmed.2020.08.001. Epub 2020 Sep 17.PMID: 32952044
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J.Nat Commun. 2021 Jan 29;12(1):707. doi: 10.1038/s41467-021-20942-w.PMID: 33514727
2020
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T.J Cell Mol Med. 2020 Jun;24(11):5937-5954. doi: 10.1111/jcmm.15180. Epub 2020 May 8.PMID: 32384583
Mechanism of succinate efflux upon reperfusion of the ischemic heart.
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D.Cardiovasc Res. 2020 Aug 7:cvaa148. doi: 10.1093/cvr/cvaa148. Online ahead of print.PMID: 32766828
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.
Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT.J Cell Mol Med. 2020 Mar;24(6):3534-3548. doi: 10.1111/jcmm.15043. Epub 2020 Feb 10.PMID: 32040259
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Park M, Nishimura T, Baeza-Garza CD, Caldwell ST, Pun PBL, Prag HA, Young T, Sauchanka O, Logan A, Forkink M, Gruszczyk AV, Prime TA, Arndt S, Naudi A, Pamplona R, Coughlan MT, Tate M, Ritchie RH, Caicci F, Kaludercic N, Di Lisa F, Smith RAJ, Hartley RC, Murphy MP, Krieg T.Cardiovasc Drugs Ther. 2020 Dec;34(6):823-834. doi: 10.1007/s10557-020-07086-7. Epub 2020 Sep 26.
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T. Cardiovasc Drugs Ther. 2020 Jul 9. doi: 10.1007/s10557-020-07033-6. Online ahead of print.PMID: 32648168
2019
Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.
Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T. Basic Res Cardiol. 2019 Mar 15;114(3):18. doi: 10.1007/s00395-019-0727-0.PMID: 30877396
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y.PMID: 32395697
Targeting Succinate Metabolism in Ischemia/Reperfusion Injury.
Kula-Alwar D, Prag HA, Krieg T. Circulation. 2019 Dec 10;140(24):1968-1970. doi: 10.1161/CIRCULATIONAHA.119.042791. Epub 2019 Dec 9.PMID: 31815541 Review.
The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.
Tate M, Higgins GC, De Blasio MJ, Lindblom R, Prakoso D, Deo M, Kiriazis H, Park M, Baeza-Garza CD, Caldwell ST, Hartley RC, Krieg T, Murphy MP, Coughlan MT, Ritchie RH.Cardiovasc Drugs Ther. 2019 Dec;33(6):669-674. doi: 10.1007/s10557-019-06914-9.PMID: 31654171
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP. Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31.PMID: 30713096
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.
Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. Free Radic Biol Med. 2019 Apr;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. Epub 2019 Feb 4.PMID: 30731114
2018
Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury.
Matthias Kohlhauer, Sam Dawkins, Ana S. H. Costa, Regent Lee, Timothy Young, Victoria R. Pell, Robin P. Choudhury, Adrian P. Banning, Rajesh K. Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb‐Parsy, Michael P. Murphy, Christian Frezza, Thomas Krieg, Keith M. Channon
JAHA. 2018 Apr https://doi.org/10.1161/JAHA.117.007546
2017
Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.
Chouchani ET, James AM, Methner C, Pell VR, Prime TA, Erickson BK, Forkink M, Lau GY, Bright TP, Menger KE, Fearnley IM, Krieg T, Murphy MP.
J Biol Chem. 2017 Sep 1;292(35):14486-14495. doi: 10.1074/jbc.M117.798744. Epub 2017 Jul 14. PMID: 28710281
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Pell VR, Chouchani ET, Frezza C, Murphy MP, Krieg T.
Cardiovasc Res. 2016 Jul 15;111(2):134-41. doi: 10.1093/cvr/cvw100. Epub 2016 May 18. Review.
Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T.
Circ Res. 2016 Mar 4;118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569. Review.
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP.
Cell Metab. 2016 Feb 9;23(2):254-63. doi: 10.1016/j.cmet.2015.12.009. Epub 2016 Jan 14. Review.
2023
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Mottahedin A, Prag HA, Dannhorn A, Mair R, Schmidt C, Yang M, Sorby-Adams A, Lee JJ, Burger N, Kulaveerasingam D, Huang MM, Pluchino S, Peruzzotti-Jametti L, Goodwin R, Frezza C, Murphy MP, Krieg T.Redox Biol. 2023 Feb;59:102600. doi: 10.1016/j.redox.2023.102600. Epub 2023 Jan 2.PMID: 36630820
2022
Cyclophilin D knockout mice do not accumulate succinate during cardiac ischemia.
Prag HA, Kula-Alwar D, Bernardi P, Di Lisa F, Murphy MP, Krieg T.J Mol Cell Cardiol. 2022 Dec;173:73-74. doi: 10.1016/j.yjmcc.2022.09.006. Epub 2022 Oct 6.PMID: 36209553
Ischemia-Selective Cardioprotection by Malonate for Ischemia/Reperfusion Injury.
Prag HA, Aksentijevic D, Dannhorn A, Giles AV, Mulvey JF, Sauchanka O, Du L, Bates G, Reinhold J, Kula-Alwar D, Xu Z, Pellerin L, Goodwin RJA, Murphy MP, Krieg T.Circ Res. 2022 Sep 2;131(6):528-541. doi: 10.1161/CIRCRESAHA.121.320717. Epub 2022 Aug 12.PMID: 35959683
ND3 Cys39 in complex I is exposed during mitochondrial respiration.
Burger N, James AM, Mulvey JF, Hoogewijs K, Ding S, Fearnley IM, Loureiro-López M, Norman AAI, Arndt S, Mottahedin A, Sauchanka O, Hartley RC, Krieg T, Murphy MP.Cell Chem Biol. 2022 Apr 21;29(4):636-649.e14. doi: 10.1016/j.chembiol.2021.10.010. Epub 2021 Nov 4.PMID: 34739852
Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury.
Miljkovic JL, Burger N, Gawel JM, Mulvey JF, Norman AAI, Nishimura T, Tsujihata Y, Logan A, Sauchanka O, Caldwell ST, Morris JL, Prime TA, Warrington S, Prudent J, Bates GR, Aksentijević D, Prag HA, James AM, Krieg T, Hartley RC, Murphy MP.Redox Biol. 2022 Aug 5;55:102429. doi: 10.1016/j.redox.2022.102429. Online ahead of print.PMID: 35961099
2021
Mitochondria as Therapeutic Targets in Transplantation.
Saeb-Parsy K, Martin JL, Summers DM, Watson CJE, Krieg T, Murphy MP.Trends Mol Med. 2021 Feb;27(2):185-198. doi: 10.1016/j.molmed.2020.08.001. Epub 2020 Sep 17.PMID: 32952044
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J.Nat Commun. 2021 Jan 29;12(1):707. doi: 10.1038/s41467-021-20942-w.PMID: 33514727
2020
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T.J Cell Mol Med. 2020 Jun;24(11):5937-5954. doi: 10.1111/jcmm.15180. Epub 2020 May 8.PMID: 32384583
Mechanism of succinate efflux upon reperfusion of the ischemic heart.
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D.Cardiovasc Res. 2020 Aug 7:cvaa148. doi: 10.1093/cvr/cvaa148. Online ahead of print.PMID: 32766828
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.
Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT.J Cell Mol Med. 2020 Mar;24(6):3534-3548. doi: 10.1111/jcmm.15043. Epub 2020 Feb 10.PMID: 32040259
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Park M, Nishimura T, Baeza-Garza CD, Caldwell ST, Pun PBL, Prag HA, Young T, Sauchanka O, Logan A, Forkink M, Gruszczyk AV, Prime TA, Arndt S, Naudi A, Pamplona R, Coughlan MT, Tate M, Ritchie RH, Caicci F, Kaludercic N, Di Lisa F, Smith RAJ, Hartley RC, Murphy MP, Krieg T.Cardiovasc Drugs Ther. 2020 Dec;34(6):823-834. doi: 10.1007/s10557-020-07086-7. Epub 2020 Sep 26.
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T. Cardiovasc Drugs Ther. 2020 Jul 9. doi: 10.1007/s10557-020-07033-6. Online ahead of print.PMID: 32648168
2019
Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.
Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T. Basic Res Cardiol. 2019 Mar 15;114(3):18. doi: 10.1007/s00395-019-0727-0.PMID: 30877396
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y.PMID: 32395697
Targeting Succinate Metabolism in Ischemia/Reperfusion Injury.
Kula-Alwar D, Prag HA, Krieg T. Circulation. 2019 Dec 10;140(24):1968-1970. doi: 10.1161/CIRCULATIONAHA.119.042791. Epub 2019 Dec 9.PMID: 31815541 Review.
The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.
Tate M, Higgins GC, De Blasio MJ, Lindblom R, Prakoso D, Deo M, Kiriazis H, Park M, Baeza-Garza CD, Caldwell ST, Hartley RC, Krieg T, Murphy MP, Coughlan MT, Ritchie RH.Cardiovasc Drugs Ther. 2019 Dec;33(6):669-674. doi: 10.1007/s10557-019-06914-9.PMID: 31654171
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP. Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31.PMID: 30713096
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.
Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. Free Radic Biol Med. 2019 Apr;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. Epub 2019 Feb 4.PMID: 30731114
2018
Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury.
Matthias Kohlhauer, Sam Dawkins, Ana S. H. Costa, Regent Lee, Timothy Young, Victoria R. Pell, Robin P. Choudhury, Adrian P. Banning, Rajesh K. Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb‐Parsy, Michael P. Murphy, Christian Frezza, Thomas Krieg, Keith M. Channon
JAHA. 2018 Apr https://doi.org/10.1161/JAHA.117.007546
2017
Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.
Chouchani ET, James AM, Methner C, Pell VR, Prime TA, Erickson BK, Forkink M, Lau GY, Bright TP, Menger KE, Fearnley IM, Krieg T, Murphy MP.
J Biol Chem. 2017 Sep 1;292(35):14486-14495. doi: 10.1074/jbc.M117.798744. Epub 2017 Jul 14. PMID: 28710281
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Pell VR, Chouchani ET, Frezza C, Murphy MP, Krieg T.
Cardiovasc Res. 2016 Jul 15;111(2):134-41. doi: 10.1093/cvr/cvw100. Epub 2016 May 18. Review.
Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T.
Circ Res. 2016 Mar 4;118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569. Review.
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP.
Cell Metab. 2016 Feb 9;23(2):254-63. doi: 10.1016/j.cmet.2015.12.009. Epub 2016 Jan 14. Review.
