Selected Publications
2021
Mitochondria as Therapeutic Targets in Transplantation.
Saeb-Parsy K, Martin JL, Summers DM, Watson CJE, Krieg T, Murphy MP.Trends Mol Med. 2021 Feb;27(2):185-198. doi: 10.1016/j.molmed.2020.08.001. Epub 2020 Sep 17.PMID: 32952044
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J.Nat Commun. 2021 Jan 29;12(1):707. doi: 10.1038/s41467-021-20942-w.PMID: 33514727
2020
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T.J Cell Mol Med. 2020 Jun;24(11):5937-5954. doi: 10.1111/jcmm.15180. Epub 2020 May 8.PMID: 32384583
Mechanism of succinate efflux upon reperfusion of the ischemic heart.
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D.Cardiovasc Res. 2020 Aug 7:cvaa148. doi: 10.1093/cvr/cvaa148. Online ahead of print.PMID: 32766828
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.
Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT.J Cell Mol Med. 2020 Mar;24(6):3534-3548. doi: 10.1111/jcmm.15043. Epub 2020 Feb 10.PMID: 32040259
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Park M, Nishimura T, Baeza-Garza CD, Caldwell ST, Pun PBL, Prag HA, Young T, Sauchanka O, Logan A, Forkink M, Gruszczyk AV, Prime TA, Arndt S, Naudi A, Pamplona R, Coughlan MT, Tate M, Ritchie RH, Caicci F, Kaludercic N, Di Lisa F, Smith RAJ, Hartley RC, Murphy MP, Krieg T.Cardiovasc Drugs Ther. 2020 Dec;34(6):823-834. doi: 10.1007/s10557-020-07086-7. Epub 2020 Sep 26.
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T. Cardiovasc Drugs Ther. 2020 Jul 9. doi: 10.1007/s10557-020-07033-6. Online ahead of print.PMID: 32648168
2019
Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.
Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T. Basic Res Cardiol. 2019 Mar 15;114(3):18. doi: 10.1007/s00395-019-0727-0.PMID: 30877396
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y.PMID: 32395697
Targeting Succinate Metabolism in Ischemia/Reperfusion Injury.
Kula-Alwar D, Prag HA, Krieg T. Circulation. 2019 Dec 10;140(24):1968-1970. doi: 10.1161/CIRCULATIONAHA.119.042791. Epub 2019 Dec 9.PMID: 31815541 Review.
The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.
Tate M, Higgins GC, De Blasio MJ, Lindblom R, Prakoso D, Deo M, Kiriazis H, Park M, Baeza-Garza CD, Caldwell ST, Hartley RC, Krieg T, Murphy MP, Coughlan MT, Ritchie RH.Cardiovasc Drugs Ther. 2019 Dec;33(6):669-674. doi: 10.1007/s10557-019-06914-9.PMID: 31654171
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP. Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31.PMID: 30713096
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.
Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. Free Radic Biol Med. 2019 Apr;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. Epub 2019 Feb 4.PMID: 30731114
2018
Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury.
Matthias Kohlhauer, Sam Dawkins, Ana S. H. Costa, Regent Lee, Timothy Young, Victoria R. Pell, Robin P. Choudhury, Adrian P. Banning, Rajesh K. Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb‐Parsy, Michael P. Murphy, Christian Frezza, Thomas Krieg, Keith M. Channon
JAHA. 2018 Apr https://doi.org/10.1161/JAHA.117.007546
2017
Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.
Chouchani ET, James AM, Methner C, Pell VR, Prime TA, Erickson BK, Forkink M, Lau GY, Bright TP, Menger KE, Fearnley IM, Krieg T, Murphy MP.
J Biol Chem. 2017 Sep 1;292(35):14486-14495. doi: 10.1074/jbc.M117.798744. Epub 2017 Jul 14. PMID: 28710281
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Pell VR, Chouchani ET, Frezza C, Murphy MP, Krieg T.
Cardiovasc Res. 2016 Jul 15;111(2):134-41. doi: 10.1093/cvr/cvw100. Epub 2016 May 18. Review.
Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T.
Circ Res. 2016 Mar 4;118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569. Review.
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP.
Cell Metab. 2016 Feb 9;23(2):254-63. doi: 10.1016/j.cmet.2015.12.009. Epub 2016 Jan 14. Review.
2016
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Cardiovasc Res. doi:10.1093/cvr/cvw100
Pell, V. R., Chouchani, E. T., Frezza, C., Murphy, M. P., & Krieg, T.
Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Circ Res.118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569
Pell, V.R., Chouchani, E.T., Murphy, M.P., Brookes, P.S., Krieg, T.
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Cell Metab. 23(2), 254–263. doi:10.1016/j.cmet.2015.12.009
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., Murphy, M. P.
2015
Logan A*, Pell VR*, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, Smith RAJ and Murphy MP.
Assessing the mitochondrial membrane potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.
Cell Metab. 23, 379–385. doi:10.1016/j.cmet.2015.11.014
Evans E, Buonincontri G, Izquierdo D, Methner C, Hawkes RC, Ansorge RE, Krieg T, Carpenter TA, Sawiak SJ.
Combining MRI with PET for partial volume correction improves image-derived input functions in mice.
IEEE Trans Nucl Sci. 62(3 Pt 1):628-633. doi:10.1186/2197-7364-1-S1-A84
2014
Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord EN, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa AS, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Nature. doi: 10.1038/nature13909.
Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T.
Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.
Eur J Heart Fail. 16(7):712-7. doi: 10.1002/ejhf.100.
Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter, Stephen J. Sawiak.
Trajectory correction for free-breathing radial cine MRI.
Magn Reson Imaging. doi: 10.1016/j.mri.2014.04.006.
Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter and Stephen J. Sawiak
Functional assessment of the mouse heart by MRI with a 1-min acquisition.
NMR Biomed. doi: 10.1002/nbm.3116
Edward T. Chouchani, Chou-Hui Hu, Guido Buonincontri, Carmen Methner, Angela Logan, Chou-Hui Hu, Stephen J. Sawiak, Michael P. Murphy, and Thomas Krieg. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.
PLoS One, 10.1371/journal.pone.0094157
2013
Carmen Methner, Guido Buonincontri, Chou-Hui Hu, Ana Vujic, Axel Kretschmer, Stephen Sawiak, Adrian Carpenter, Johannes-Peter Stasch, Thomas Krieg.
Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging.
PLoS One, 10.1371/journal.pone.0083910
Guido Buonincontri, Carmen Methner, T. Adrian Carpenter, Robert C. Hawkes, Stephen J. Sawiak, Thomas Krieg.
MRI and PET in mouse models of myocardial infarction.
J Vis Exp. doi: 10.3791/50806.
Edward T. Chouchani, Carmen Methner, Sergiy M. Nadtochiy, Angela Logan, Victoria R. Pell, Shujing Ding, Andrew M. James, Helena M. Cochemé, Johannes Reinhold, Kathryn S. Lilley, Linda Partridge, Ian M. Fearnley, Alan J. Robinson, Richard C. Hartley, Robin A.J. Smith, Thomas Krieg, Paul S. Brookes, and Michael P. Murphy. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.
Nature Medicine. 19, 753-759.
(Download) (Nature Medicine: News and Views) (BBC News coverage)
Angela Logan, Helena M. Cochemé, Pamela Boon Li Pun, Nadezda Apostolova, Robin A. J. Smith, Lesley Larsen, David S. Larsen, Andrew M. James, Ian M. Fearnley, Sebastian Rogatti, Tracy A. Prime, Peter Finichiu, Anna Dare, Edward T. Chouchani, Victoria R. Pell, Carmen Methner, Caroline Quin, Stephen J. McQuaker, Thomas Krieg, Richard C. Hartley, Michael P. Murphy.
Using exomarkers to assess mitochondrial reactive species in vivo.
Biochimica Biophysica Acta. 1840(2):923-30 doi: 10.1016/j.bbagen.2013.05.026.
(Download)
Carmen Methner, Robert Lukowski, Karina Grube, Florian Loga, Robin A. J. Smith, Michael P. Murphy, Franz Hofmann, Thomas Krieg.
Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G.
Basic Research in Cardiology. 108, 337.
(Download)
Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter, Stephen J. Sawiak.
A fast protocol for infarct quantification in mice.
Journal of Magnetic Resonance Imaging. 38(2):468-73. (DOI: 10.1002/jmri.24001)
(Download)
2021
Mitochondria as Therapeutic Targets in Transplantation.
Saeb-Parsy K, Martin JL, Summers DM, Watson CJE, Krieg T, Murphy MP.Trends Mol Med. 2021 Feb;27(2):185-198. doi: 10.1016/j.molmed.2020.08.001. Epub 2020 Sep 17.PMID: 32952044
Structural basis for a complex I mutation that blocks pathological ROS production.
Yin Z, Burger N, Kula-Alwar D, Aksentijević D, Bridges HR, Prag HA, Grba DN, Viscomi C, James AM, Mottahedin A, Krieg T, Murphy MP, Hirst J.Nat Commun. 2021 Jan 29;12(1):707. doi: 10.1038/s41467-021-20942-w.PMID: 33514727
2020
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Zuurbier CJ, Bertrand L, Beauloye CR, Andreadou I, Ruiz-Meana M, Jespersen NR, Kula-Alwar D, Prag HA, Eric Botker H, Dambrova M, Montessuit C, Kaambre T, Liepinsh E, Brookes PS, Krieg T.J Cell Mol Med. 2020 Jun;24(11):5937-5954. doi: 10.1111/jcmm.15180. Epub 2020 May 8.PMID: 32384583
Mechanism of succinate efflux upon reperfusion of the ischemic heart.
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D.Cardiovasc Res. 2020 Aug 7:cvaa148. doi: 10.1093/cvr/cvaa148. Online ahead of print.PMID: 32766828
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.
Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT.J Cell Mol Med. 2020 Mar;24(6):3534-3548. doi: 10.1111/jcmm.15043. Epub 2020 Feb 10.PMID: 32040259
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Park M, Nishimura T, Baeza-Garza CD, Caldwell ST, Pun PBL, Prag HA, Young T, Sauchanka O, Logan A, Forkink M, Gruszczyk AV, Prime TA, Arndt S, Naudi A, Pamplona R, Coughlan MT, Tate M, Ritchie RH, Caicci F, Kaludercic N, Di Lisa F, Smith RAJ, Hartley RC, Murphy MP, Krieg T.Cardiovasc Drugs Ther. 2020 Dec;34(6):823-834. doi: 10.1007/s10557-020-07086-7. Epub 2020 Sep 26.
Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
Prag HA, Pala L, Kula-Alwar D, Mulvey JF, Luping D, Beach TE, Booty LM, Hall AR, Logan A, Sauchanka V, Caldwell ST, Robb EL, James AM, Xu Z, Saeb-Parsy K, Hartley RC, Murphy MP, Krieg T. Cardiovasc Drugs Ther. 2020 Jul 9. doi: 10.1007/s10557-020-07033-6. Online ahead of print.PMID: 32648168
2019
Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.
Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T. Basic Res Cardiol. 2019 Mar 15;114(3):18. doi: 10.1007/s00395-019-0727-0.PMID: 30877396
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y.PMID: 32395697
Targeting Succinate Metabolism in Ischemia/Reperfusion Injury.
Kula-Alwar D, Prag HA, Krieg T. Circulation. 2019 Dec 10;140(24):1968-1970. doi: 10.1161/CIRCULATIONAHA.119.042791. Epub 2019 Dec 9.PMID: 31815541 Review.
The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.
Tate M, Higgins GC, De Blasio MJ, Lindblom R, Prakoso D, Deo M, Kiriazis H, Park M, Baeza-Garza CD, Caldwell ST, Hartley RC, Krieg T, Murphy MP, Coughlan MT, Ritchie RH.Cardiovasc Drugs Ther. 2019 Dec;33(6):669-674. doi: 10.1007/s10557-019-06914-9.PMID: 31654171
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP. Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31.PMID: 30713096
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.
Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. Free Radic Biol Med. 2019 Apr;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. Epub 2019 Feb 4.PMID: 30731114
2018
Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury.
Matthias Kohlhauer, Sam Dawkins, Ana S. H. Costa, Regent Lee, Timothy Young, Victoria R. Pell, Robin P. Choudhury, Adrian P. Banning, Rajesh K. Kharbanda, Oxford Acute Myocardial Infarction (OxAMI) Study, Kourosh Saeb‐Parsy, Michael P. Murphy, Christian Frezza, Thomas Krieg, Keith M. Channon
JAHA. 2018 Apr https://doi.org/10.1161/JAHA.117.007546
2017
Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.
Chouchani ET, James AM, Methner C, Pell VR, Prime TA, Erickson BK, Forkink M, Lau GY, Bright TP, Menger KE, Fearnley IM, Krieg T, Murphy MP.
J Biol Chem. 2017 Sep 1;292(35):14486-14495. doi: 10.1074/jbc.M117.798744. Epub 2017 Jul 14. PMID: 28710281
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Pell VR, Chouchani ET, Frezza C, Murphy MP, Krieg T.
Cardiovasc Res. 2016 Jul 15;111(2):134-41. doi: 10.1093/cvr/cvw100. Epub 2016 May 18. Review.
Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T.
Circ Res. 2016 Mar 4;118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569. Review.
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP.
Cell Metab. 2016 Feb 9;23(2):254-63. doi: 10.1016/j.cmet.2015.12.009. Epub 2016 Jan 14. Review.
2016
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Cardiovasc Res. doi:10.1093/cvr/cvw100
Pell, V. R., Chouchani, E. T., Frezza, C., Murphy, M. P., & Krieg, T.
Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.
Circ Res.118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569
Pell, V.R., Chouchani, E.T., Murphy, M.P., Brookes, P.S., Krieg, T.
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.
Cell Metab. 23(2), 254–263. doi:10.1016/j.cmet.2015.12.009
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., Murphy, M. P.
2015
Logan A*, Pell VR*, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, Smith RAJ and Murphy MP.
Assessing the mitochondrial membrane potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.
Cell Metab. 23, 379–385. doi:10.1016/j.cmet.2015.11.014
Evans E, Buonincontri G, Izquierdo D, Methner C, Hawkes RC, Ansorge RE, Krieg T, Carpenter TA, Sawiak SJ.
Combining MRI with PET for partial volume correction improves image-derived input functions in mice.
IEEE Trans Nucl Sci. 62(3 Pt 1):628-633. doi:10.1186/2197-7364-1-S1-A84
2014
Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord EN, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa AS, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Nature. doi: 10.1038/nature13909.
Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T.
Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.
Eur J Heart Fail. 16(7):712-7. doi: 10.1002/ejhf.100.
Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter, Stephen J. Sawiak.
Trajectory correction for free-breathing radial cine MRI.
Magn Reson Imaging. doi: 10.1016/j.mri.2014.04.006.
Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter and Stephen J. Sawiak
Functional assessment of the mouse heart by MRI with a 1-min acquisition.
NMR Biomed. doi: 10.1002/nbm.3116
Edward T. Chouchani, Chou-Hui Hu, Guido Buonincontri, Carmen Methner, Angela Logan, Chou-Hui Hu, Stephen J. Sawiak, Michael P. Murphy, and Thomas Krieg. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.
PLoS One, 10.1371/journal.pone.0094157
2013
Carmen Methner, Guido Buonincontri, Chou-Hui Hu, Ana Vujic, Axel Kretschmer, Stephen Sawiak, Adrian Carpenter, Johannes-Peter Stasch, Thomas Krieg.
Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging.
PLoS One, 10.1371/journal.pone.0083910
Guido Buonincontri, Carmen Methner, T. Adrian Carpenter, Robert C. Hawkes, Stephen J. Sawiak, Thomas Krieg.
MRI and PET in mouse models of myocardial infarction.
J Vis Exp. doi: 10.3791/50806.
Edward T. Chouchani, Carmen Methner, Sergiy M. Nadtochiy, Angela Logan, Victoria R. Pell, Shujing Ding, Andrew M. James, Helena M. Cochemé, Johannes Reinhold, Kathryn S. Lilley, Linda Partridge, Ian M. Fearnley, Alan J. Robinson, Richard C. Hartley, Robin A.J. Smith, Thomas Krieg, Paul S. Brookes, and Michael P. Murphy. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.
Nature Medicine. 19, 753-759.
(Download) (Nature Medicine: News and Views) (BBC News coverage)
Angela Logan, Helena M. Cochemé, Pamela Boon Li Pun, Nadezda Apostolova, Robin A. J. Smith, Lesley Larsen, David S. Larsen, Andrew M. James, Ian M. Fearnley, Sebastian Rogatti, Tracy A. Prime, Peter Finichiu, Anna Dare, Edward T. Chouchani, Victoria R. Pell, Carmen Methner, Caroline Quin, Stephen J. McQuaker, Thomas Krieg, Richard C. Hartley, Michael P. Murphy.
Using exomarkers to assess mitochondrial reactive species in vivo.
Biochimica Biophysica Acta. 1840(2):923-30 doi: 10.1016/j.bbagen.2013.05.026.
(Download)
Carmen Methner, Robert Lukowski, Karina Grube, Florian Loga, Robin A. J. Smith, Michael P. Murphy, Franz Hofmann, Thomas Krieg.
Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G.
Basic Research in Cardiology. 108, 337.
(Download)
Guido Buonincontri, Carmen Methner, Thomas Krieg, T. Adrian Carpenter, Stephen J. Sawiak.
A fast protocol for infarct quantification in mice.
Journal of Magnetic Resonance Imaging. 38(2):468-73. (DOI: 10.1002/jmri.24001)
(Download)
